Dr. Chow received his PhD in Chemical Engineering from the University of Washington. After completing his PhD, Dr. Chow remained in Seattle pursuing post-doctoral research work in Immunology at the Fred Hutchinson Cancer Research Center and the Benaroya Research Institute at Virginia Mason. Dr. Chow has been actively participating in the innovation of tetramer technologies since joining the Benaroya Research Institute and is currently the manager of the tetramer core.
Area of Research
Dr. Chow’s research projects are focused on understanding the immunopathology and regulation of disease-triggering helper T lymphocytes in autoimmune disorders. The primary objective of his work emphasizes on obtaining in-depth immune profiling of antigen-specific T lymphocytes that can be potential prognostic, diagnostic, and therapeutic biomarkers for autoimmunity diseases. Translational data from these studies using novel tetramer-based technologies and peptide-linked tetramer reagents will provide important avenues for new drug targets and evaluation of treatment efficacy.
1. Uchtenhagen H, Rims C, Blahnik G, Chow IT, Kwok WW, Buckner JH, James, EA, "Efficient ex vivo analysis of CD4+ T cell responses using combinatorial HLA-class II tetramer staining" Nat. Commun. 12614, 2016.
2. Archila LD, Chow IT, McGinty JW, Renand A, Jeong D, Robinson, D, Farrington ML, Kwok WW, " Ana o 1 and Ana o 2 cashew allergens share cross-reactive CD4+ T-cell epitopes with other tree nuts" Clin Exp Allergy 46(6): 871-883, 2016.
3. Chow IT, Yang J, Gates TJ, James EA, Duy TM, Greenbaum C, and Kwok WW, "Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development" PLoS ONE 9(11) 2014.
4. Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum C, James EA, Kappler JW, Davidson HW, and Kwok WW, "Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes" Proc. Natl. Acad. Sci. USA 111(41): 14850-14845, 2014.
5. McGinty JW, Chow IT, Odegard JM, Greenbaum C, Kwok WW, and James EA, "Recognition of post-translationally modified glutamic acid decarboxylase 65 epitopes in subjects with type 1 diabetes" Diabetes 63(9): 3033-3040, 2014.
6. Chow IT, James EA, Gates TJ, Tan V, Moustakas AK, Papadopoulos GK, and Kwok WW, "Differential binding of pyruvate dehydrogenase complex-E2 (PDC-E2) epitopes by DRB1*08:01 and DRB1*11:01 is predicted by their structural motifs and correlates with disease risk" J. Immunol. 190(9):4516-24, 2013.
7. Chow IT, James EA, Tan V, Moustakas AK, Papadopoulos GK, and Kwok WW, "DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in packet 9" Mol. Immunol. 50(1-2):26-32, 2012.
8. *Kaiser BK, *Yim D, *Chow IT, Gonzalez S, Dai Z, Mann HH, Strong RK, Groh V and Spies T, "Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands", Nature 447: 482-486, 2007. *Contributed equally to this work.
9. Chow IT, Barnett M, Zolkiewski M, and Baneyx F, "The N-terminal domain of Escherichia coli ClpB enhances chaperone function", FEBS Lett. 579: 4242-4248, 2005.
10. Chow IT and Baneyx F, "Coordinated synthesis of the two ClpB isoforms improves the ability of Escherichia coli to survive thermal stress", FEBS Lett. 579: 4235-4241, 2005.
11. Tsai WY, Chow IT, Chen HR, Huang KT, Hong RI, Jan SP, Kuo NY, Tsao TY, Chen CH, and Cheng SC, "Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing", J. Biol. Chem. 274: 9455-9462, 1999.